Spruce Biosciences (SPRB) +1,400% on FDA Breakthrough News

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Spruce Biosciences (SPRB) surged over 1,400% in one day after the U.S. FDA granted Breakthrough Therapy Designation for its experimental enzyme replacement therapy, Tralesinidase Alfa (TA-ERT), which targets Sanfilippo Syndrome Type B (MPS IIIB) — a rare and deadly genetic disorder.
The designation fast-tracks development and review, signaling strong confidence in the drug’s potential and marking one of the biggest single-day gains for a biotech stock this year.

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Crypto Crash: Record $19B Wipeout

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Crypto markets suffered their worst crash ever after Trump’s new China tariff announcement sent shockwaves through global markets.
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Bitcoin plunged from $126,000 to $105,000 within hours, while other major coins like Ethereum, Cardano, and Chainlink lost significant value.
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Data from CoinGlass showed over $19 billion in crypto bets were wiped out — the largest one-day loss in crypto history, far surpassing the FTX collapse and COVID crash.
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Much of the damage came from traders using borrowed money (leverage) to boost their bets. When prices fell, their positions were automatically sold to cover losses — triggering a cascade of forced selling that deepened the crash.
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Crypto-linked stocks also tumbled: Coinbase (COIN) fell nearly 10%, and MicroStrategy (MSTR) dropped about 7% as investor panic spread. Even Trump’s own WLFI token sank nearly 50% before partially recovering.
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The selloff showed how quickly the crypto market can unravel when heavy speculation meets sudden political shocks.